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Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations

Lydia Gutierrez-Gonzalez, Maesha Deheragoda, George Elia, Simon J Leedham, Arjun Shankar, Charles Imber, Janusz A Jankowski, Douglass M Turnbull, Marco Novelli, Nicholas A Wright, Stuart AC McDonald

Journal:

The Journal of Pathology

Année:

2009

Langue:

english

Fichier:

PDF, 588 KB

english, 2009

Stem cells and cancer: a deadly mix

Malcolm R. Alison, George Murphy, Simon Leedham

Journal:

Cell and Tissue Research

Année:

2008

Langue:

english

Fichier:

PDF, 508 KB

english, 2008

Genetics of inflammatory bowel disease and associated cancers

Simon J. Leedham, Janusz A. Jankowski, Nicholas A. Wright, Ian P. M. Tomlinson

Journal:

Current Colorectal Cancer Reports

Année:

2006

Langue:

english

Fichier:

PDF, 218 KB

english, 2006

Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus?

Wozniak, Matthew A, Shipley, Suzanne J, Dobson, Curtis B, Parker, Simon P, Scott, Fiona T, Leedham-Green, Mary, Breuer, Judy, Itzhaki, Ruth F

Journal:

European Journal of Human Genetics

Année:

2007

Langue:

english

Fichier:

PDF, 95 KB

english, 2007

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Jaeger, Emma, Leedham, Simon, Lewis, Annabelle, Segditsas, Stefania, Becker, Martin, Cuadrado, Pedro Rodenas, Davis, Hayley, Kaur, Kulvinder, Heinimann, Karl, Howarth, Kimberley, East, James, Taylor,

Journal:

Nature Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 579 KB

english, 2012

The safety of autologous fat transfer in breast cancer: Lessons from stem cell biology

Robert A. Pearl, Simon J. Leedham, Marc D. Pacifico

Journal:

Journal of Plastic, Reconstructive & Aesthetic Surgery

Année:

2012

Langue:

english

Fichier:

PDF, 129 KB

english, 2012

484 Methylation and Clonality of Human Colonic Crypts

Trevor A. Graham, Adam Humphries, Stuart A. McDonald, Simon Leedham, Nicholas A. Wright

Journal:

Gastroenterology

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

1086 The Clonal Origins of Dysplasia from Metaplasia in the Human Stomach

Lydia Gutierrez, Manuel Rodriguez-Justo, Simon Leedham, David Stoker, Ian Mitchell, Marco Novelli, Janusz A. Jankowski, Nicholas A. Wright, Stuart A. McDonald

Journal:

Gastroenterology

Année:

2009

Langue:

english

Fichier:

PDF, 53 KB

english, 2009

902 Investigating Clonal Competition in Barrett's Associated Tumorigenesis Using Spatial Maps of Genetic Heterogeneity

Trevor A. Graham, Shabuddin Khan, Dahmane Oukrif, Alicia E. Green, Laura J. Gay, Hugh Barr, Marco Novelli, Janusz A. Jankowski, Neil A. Shepherd, Simon Leedham, Stuart A. McDonald, Nicholas A. Wright

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 46 KB

english, 2010

Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient

Pedro Rodenas-Cuadrado, Kimberley Howarth, Annabelle Lewis, Sreelakshmi Mallappa, Rosemary Jeffery, Manuel Rodriguez-Justo, Susan K. Clark, James E. East, Simon Travis, Ian Tomlinson, Simon Leedham

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 44 KB

english, 2011

551 Hereditary Mixed Polyposis Syndrome is Caused by a 40kb Upstream Duplication That Leads to Increased and Ectopic Expression of the BMP Antagonist Grem1

Simon Leedham, Jaeger Emma, Annabelle Lewis, Stefania Segditsas, Martin Becker, James East, Jenny Taylor, Huw J. Thomas, Ian Tomlinson

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 283 KB

english, 2012

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

Stuart A.C. McDonald, Laura C. Greaves, Lydia Gutierrez–Gonzalez, Manuel Rodriguez–Justo, Maesha Deheragoda, Simon J. Leedham, Robert W. Taylor, Chung Yin Lee, Sean L. Preston, Matthew Lovell, Toby Hu

Journal:

Gastroenterology

Année:

2008

Langue:

english

Fichier:

PDF, 5.54 MB

english, 2008

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

Simon J. Leedham, Trevor A. Graham, Dahmane Oukrif, Stuart A.C. McDonald, Manuel Rodriguez–Justo, Rebecca F. Harrison, Neil A. Shepherd, Marco R. Novelli, Janusz A.Z. Jankowski, Nicholas A. Wright

Journal:

Gastroenterology

Année:

2009

Langue:

english

Fichier:

PDF, 3.25 MB

english, 2009

Use of Methylation Patterns to Determine Expansion of Stem Cell Clones in Human Colon Tissue

Trevor A. Graham, Adam Humphries, Theodore Sanders, Manuel Rodriguez–Justo, Paul J. Tadrous, Sean L. Preston, Marco R. Novelli, Simon J. Leedham, Stuart A.C. McDonald, Nicholas A. Wright

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 6.18 MB

english, 2011

The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach

Lydia Gutierrez–Gonzalez, Trevor A. Graham, Manuel Rodriguez–Justo, Simon J. Leedham, Marco R. Novelli, Laura J. Gay, Tania Ventayol–Garcia, Alicia Green, Ian Mitchell, David L. Stoker, Sean L. Presto

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 8.26 MB

english, 2011

Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis

Susan Galandiuk, Manuel Rodriguez–Justo, Rosemary Jeffery, Anna M. Nicholson, Yong Cheng, Dahmane Oukrif, George Elia, Simon J. Leedham, Stuart A.C. McDonald, Nicholas A. Wright, Trevor A. Graham

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 8.13 MB

english, 2012

Reply to "The classification of intestinal polyposis"

Tomlinson, Ian, Jaeger, Emma, Leedham, Simon, Thomas, Huw

Journal:

Nature Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 111 KB

english, 2012

Left-sided sessile serrated polyps/adenomas

Chetty, Runjan, Wang, Lai Mun, Gill, Pelvender, East, James E., Leedham, Simon

Journal:

Human Pathology

Année:

2013

Langue:

english

Fichier:

PDF, 65 KB

english, 2013

Field and laboratory measurements of the rapid remobilization of plutonium from estuarine sediments

Chetty, Runjan, Wang, Lai Mun, Gill, Pelvender, East, James E., Leedham, Simon

Journal:

Deep Sea Research Part B. Oceanographic Literature Review

Année:

1990

Langue:

english

Fichier:

PDF, 81 KB

english, 1990

T1738 Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA in Situ Hybridisation

McDonald, Stuart A., Jeffery, Rosemary, Humphries, Adam, Leedham, Simon, Graham, Trevor A., Lewis, Annabelle, Segditsas, Stefania, Rodriguez-Justo, Manuel, Nicholson, Anna M., Novelli, Marco, Bamba, S

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 65 KB

english, 2010

Mo1623 Barretts Related Adenocarcinomas Arise as a Monoclonal Outgrowth From Polyclonal Dysplasia

Zeki, Sebastian S., Khan, Shabuddin, Graham, Trevor A., Leedham, Simon, Barr, Hugh, Shepherd, Neil A., Novelli, Marco, Rodriguez-Justo, Manuel, Wright, Nicholas A., McDonald, Stuart A.

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 80 KB

english, 2012

110 Aberrant Epithelial Expression of the BMP Antagonist GREMLIN1 in Human Colorectal Lesions and a Mouse Model of Hereditary Mixed Polyposis Syndrome (HMPS) Acts via Promotion of a Stem-Cell Phenotype

Davis, Hayley L., Cuadrado, Pedro Rodenas, Bardella, Chiara, Lewis, Annabelle, Emma, Jaeger, Mallappa, Sreelakshmi, Clark, Susan K., East, James, Chetty, Runjan, Tomlinson, Ian, Leedham, Simon

Journal:

Gastroenterology

Année:

2013

Langue:

english

Fichier:

PDF, 48 KB

english, 2013

Measuring stem cell dynamics in the human colon - where there's a wiggle, there's a way

Leedham, Simon J

Journal:

The Journal of Pathology

Année:

2014

Langue:

english

Fichier:

PDF, 486 KB

english, 2014

The Evidence Base of Proton Pump Inhibitor Chemopreventative Agents in Barrett's Esophagus?The Good, The Bad, and The Flawed!

Leedham, Simon, Jankowski, Janusz

Journal:

American Journal of Gastroenterology

Année:

2007

Langue:

english

Fichier:

PDF, 55 KB

english, 2007

Colonoscopy, tumors

East, James, Leedham, Simon

Journal:

Endoscopy

Année:

2014

Langue:

english

Fichier:

PDF, 180 KB

english, 2014

Wnt disruption in colorectal polyps - the traditional serrated adenoma enters the fray

Leedham, Simon J, Chetty, Runjan

Journal:

The Journal of Pathology

Année:

2016

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2016

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

Biswas, Sujata, Davis, Hayley, Irshad, Shazia, Sandberg, Tessa, Worthley, Daniel, Leedham, Simon

Journal:

The Journal of Pathology

Année:

2015

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2015

MAP(K)ing the Path to Stem Cell Quiescence and the Elusive Enteroendocrine Cell

Leedham, Simon J.

Journal:

Cell Stem Cell

Année:

2017

Langue:

english

Fichier:

PDF, 70 KB

english, 2017

British Society of Gastroenterology position statement on serrated polyps in the colon and rectum

East, James E, Atkin, Wendy S, Bateman, Adrian C, Clark, Susan K, Dolwani, Sunil, Ket, Shara N, Leedham, Simon J, Phull, Perminder S, Rutter, Matt D, Shepherd, Neil A, Tomlinson, Ian, Rees, Colin J

Journal:

Gut

Année:

2017

Langue:

english

Fichier:

PDF, 5.58 MB

english, 2017

Clonal Interactions as Mechanisms of Polyclonality in Colorectal Adenomas

Walther, Viola, Davis, Hayley, Owusu, Christian K., Sivaharan, Ashwin, Williams, Marc, Rodriguez-Justo, Manuel, Jansen, Marnix, Leedham, Simon, Graham, Trevor A., McDonald, Stuart A.

Journal:

Gastroenterology

Année:

2017

Langue:

english

Fichier:

PDF, 252 KB

english, 2017

Young GI angle: Effective data presentation

Salaga, Maciej, Leedham, Simon

Journal:

United European Gastroenterology Journal

Année:

2017

Langue:

english

Fichier:

PDF, 105 KB

english, 2017

Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel

Fernandez-Rozadilla, Ceres, Kartsonaki, Christiana, Woolley, Connor, McClellan, Michael, Whittington, Deb, Horgan, Gareth, Leedham, Simon, Kriaucionis, Skirmantas, East, James, Tomlinson, Ian

Journal:

British Journal of Cancer

Année:

2018

Langue:

english

Fichier:

PDF, 363 KB

english, 2018

The metaplastic mosaic of Barrett’s oesophagus

Biswas, Sujata, Quante, Michael, Leedham, Simon, Jansen, Marnix

Journal:

Virchows Archiv

Année:

2018

Langue:

english

Fichier:

PDF, 14.30 MB

english, 2018

Author Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel

Fernandez-Rozadilla, Ceres, Kartsonaki, Christiana, Woolley, Connor, McClellan, Michael, Whittington, Deb, Horgan, Gareth, Leedham, Simon, Kriaucionis, Skirmantas, East, James E., Tomlinson, Ian

Journal:

British Journal of Cancer

Année:

2018

Langue:

english

Fichier:

PDF, 210 KB

english, 2018

Intestine, Heal Thyself! Regulating the Intestinal Epithelial Response to Injury

Leedham, Simon J.

Journal:

CMGH Cellular and Molecular Gastroenterology and Hepatology

Année:

2020

Langue:

english

Fichier:

PDF, 149 KB

english, 2020

Gremlin 1 â small protein, big impact: the multiorgan consequences of disrupted BMP antagonism

Gooding, Sarah, Leedham, Simon J.

Journal:

The Journal of Pathology

Année:

2020

Fichier:

PDF, 1.87 MB

2020

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Sirinukunwattana, Korsuk, Domingo, Enric, Richman, Susan D, Redmond, Keara L, Blake, Andrew, Verrill, Clare, Leedham, Simon J, Chatzipli, Aikaterini, Hardy, Claire, Whalley, Celina M, Wu, Chieh-hsi, B

Journal:

Gut

Année:

2020

Fichier:

PDF, 7.37 MB

2020

770 GENERATION OF A GASTRIC ADENOCARCINOMA AND PROXIMAL POLYPOSIS OF THE STOMACH (GAPPS) MOUSE THAT PHENOCOPIES HUMAN DISEASE

Suzuki, Nobumi, Wright, Josephine, Kobayashi, Hiroki, Wang, Tongtong, Ichinose, Mari, Vrbanac, Laura, Ng, Jia, Gieniec, Krystyna, Lannagan, Tamsin, Fujiwara, Hiroaki, Enomoto, Atsushi, Leedham, Simon,

Journal:

Gastroenterology

Année:

2020

Fichier:

PDF, 278 KB

2020

[BMJ Publishing Group Ltd and British Society of Gastroenterology British Society of Gastroenterology, Annual General Meeting, 4â7 June 2018, Abstracts - ()] IBD - OTU-004âShallow whole-genome sequencing predicts the future cancer risk of low-grade dysplastic lesions in ulcerative colitis

Bakir, Ibrahim Al, Curtius, Kathleen, Baker, Anne-Marie, Clarke, Theo SO, Moorghen, Morgan, Jansen, Marnix, Rodriguez-Justo, Manuel, Leedham, Simon, Hart, Ailsa, Graham, Trevor

Fichier:

PDF, 314 KB

Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer

Kleeman, Sam O., Leedham, Simon J.

Journal:

Cancers

Année:

2020

Fichier:

PDF, 1.60 MB

2020